TGen and City of Hope announce letter of intent to develop new

first_imgReviewed by James Ives, M.Psych. (Editor)Nov 5 2018City of Hope, a world-renowned independent cancer research and treatment center, and its affiliate, Translational Genomics Research Institute (TGen), have announced a letter of intent to develop a state-of-the-art cell therapy manufacturing facility in the Phoenix Metropolitan Area, a move that would improve the speed at which stem cell research and cancer treatment is delivered.The Phoenix facility would model City of Hope’s three Current Good Manufacturing Practice (cGMP) facilities in Duarte, California, which have produced well over 1,300 cell and gene therapy products and oncology drugs for many cancer clinical trials across the nation. City of Hope is one of a small number of select cancer centers in the U.S. to provide both biological and chemical GMP manufacturing at a single institution. Its facilities have the ability to produce both gene therapy viruses and cells needed for CAR T therapies.”City of Hope is dedicated to innovation in biomedical science and has one of the most comprehensive CAR T cell programs in the world with 16 ongoing CAR T clinical trials,” said Robert W. Stone, president and chief executive officer of City of Hope as well as vice chairman of the TGen board of directors. “Cancer patients need effective treatments now. City of Hope and TGen are working to quickly move effective therapies from the laboratory to patients’ bedside. Additional cGMP facilities will help us expand our capabilities to serve people in Arizona and across the nation.”Demand for clinical cell therapies is expected to grow 42 percent annually over the next decade, according to “Cell Therapy Manufacturing Market.” Most cell therapy manufacturing facilities are at capacity or over capacity because demand is outpacing production rates.”This significant investment further enhances Arizona’s reputation as a hub for bioscience and health care innovation,” said Arizona Governor Doug Ducey. “Our state offers a strong concentration of talent ready to meet the needs of this facility. The work being conducted by City of Hope and TGen is critical in the fight against cancer, and Arizona is proud to play a role in it.”Related StoriesAlternate cell growth pathway could open door to new treatments for metastatic cancersStudy: Megakaryocytes play an important role in cell migrationSlug serves as ‘command central’ for determining breast stem cell healthThe planned facility would meet an urgent need of accelerating cures for patients in Arizona, Southern California and elsewhere. The facility would also provide additional opportunities to partner and collaborate with scientists in Arizona, an important objective for TGen, an affiliate of City of Hope.At this future facility, chimeric antigen receptor (CAR) T cells, which have demonstrated durable cancer remission in blood cancers such as leukemia and lymphoma, would be among the cells that are produced. The new facility could also support the cell therapy production needs of pharmaceutical and biotechnology companies who need this kind of specialized GMP capability to move clinical trial programs forward.”The road to future cancer cures requires genomic-enabled medicine and the type of immune-system enhancements that would result from this cell therapy manufacturing facility, which will provide local access to new treatments for Arizona patients,” said Jeffrey Trent, Ph.D., TGen president and research director. “City of Hope’s clinical and manufacturing expertise in immunotherapy is at the forefront of this field, and combined with TGen’s genomic testing, offers patients new hope for their future.”The Arizona Commerce Authority will work in partnership with City of Hope and TGen to provide workforce development assistance through its Navigator and local One-Stop programs. Source:https://www.tgen.org/news/2018/november/01/city-of-hope-tgen-intend-cell-therapy-facility/last_img read more


Researchers reveal method to produce the perfect cheese fondue

first_img Source:https://www.acs.org/content/acs/en/pressroom/presspacs/2019/acs-presspac-february-20-2019/a-scientific-method-for-perfect-fondue.html Reviewed by Kate Anderton, B.Sc. (Editor)Feb 20 2019Cheese fondue is an icon of Swiss cuisine and a dinner party staple. While it may seem like a simple dish, getting the texture right can be a challenge for optimal mouthfeel, dipping and flavor release. This requires the perfect balance of cheese, wine and starch. Now, researchers reporting in ACS Omega reveal how to use these key ingredients to produce deliciously melted fondue.Once a fad of the 1970s, fondue has made a resurgence in recent years. And on a cold winter night, there’s nothing better than dipping a piece of bread into warm, gooey cheese. But that’s only part of the picture. Traditional versions also include wine and seasonings, as well as starch for cohesion. Chemically speaking, fondue is a multiphase system of colloids that require just the right inputs to achieve cheesy perfection. One wrong move could leave the preparer with an unappetizing bowl of separated cheese solids and oils. So, to gain further insight into the flow of fondue, Pascal Bertsch, Laura Savorani and Peter Fischer wanted to assess the effect of starch and wine on the dish.Related StoriesSchwann cells capable of generating protective myelin over nerves finds researchAXT enhances cellular research product portfolio with solutions from StemBioSysTAU’s new Translational Medical Research Center acquires MILabs’ VECTor PET/SPECT/CTThe researchers started with equal amounts of two traditional fondue cheeses — Gruyère and Vacherin — in water. The addition of a potato starch slurry prevented irreversible separation of the dish. To mimic the effects of wine, they added a mixture of water and ethanol. This decreased the viscosity of the fondue, which is required for optimal mouthfeel and dipping coverage. They also incorporated acid to study the effect of lowering the pH, and this generally had the effect of lowering the fondue’s viscosity. The researchers also explored alternative thickening agents. Less carrageenan and xanthan gum were required compared to the amount of potato starch needed, but it was carrageenan that provided the creamiest results. Overall, the study shows that a few minor tweaks can result in cheesy perfection every time the fondue pot is brought out.last_img read more


Samara Polytech scientists develop simulators for the lower jaw

first_imgA plastic 3D model of a unique device that fits over the head and fastens on the jaw followed the calculations and drawings.” Anatoly Litikov, head of the laboratory of the “Building Mechanics and Resistance of Materials” department of the Samara Polytechnic Faculty of Industrial and Civil Engineering Source:Samara Polytech (Samara State Technical University) The device operates in two planes: sagittal (up – down) and frontal (left – right). Following the guide the jaw as well.The resulting simulator must take into account all the peculiarities of the movement of the human lower jaw.Now this device, up to each node, is patented.center_img Reviewed by Kate Anderton, B.Sc. (Editor)May 30 2019Today, according to various estimates, up to 60 percent of the world’s population suffers from TMJ pathologies. Unfortunately, there is still no effective solution to this problem. There are simple models of simulators for the lower jaw, but their use is fraught with some difficulties.According to the orthopedic dentist who deals with this topic, Yulia Reshetnikova, the existing simulators do not allow patients to independently develop the muscles of the maxillofacial area, and specialists cannot monitor the treatment process by setting the impact forces and the amplitude of the opening of the jaw.In general, TMJ pathologies are considered complex and multidisciplinary. Not only dentists, but also vertebrologists, chiropractors and neurologists are often involved in their treatment. A group of scientists from Samara State Medical University under the leadership of Professor Dmitry Trunin decided to seek help from engineers.For scientists of the Samara Polytech, the topic was absolutely new. They had to delve into it from scratch.last_img read more


Study could lead to new strategies for slowing the growth of glioblastoma

first_imgThe field has postulated for years that cancer stem cells are a small population within the tumor but critical because they mediate treatment resistance and cancer resistance. We’ve now found proof of that speculation.”Dr. Sunit Das, a scientist at St. Michael’s Keenan Research Centre for Biomedical Science and The Arthur and Sonia Labatt Brain Tumor Research Centre at SickKids Reviewed by Alina Shrourou, B.Sc. (Editor)Jul 10 2019Researchers are hopeful that new strategies could emerge for slowing the growth and recurrence of the most common primary brain cancer in adults, glioblastoma, based on the results of a study published today in Cancer Research.Research led by Toronto’s St. Michael’s Hospital and The Hospital for Sick Children (SickKids) suggests the protein ID1 is critical to tumor initiation and growth and also impacts the disease’s response to chemotherapy. ID1 is a protein that keeps other genes from being activated or repressed by binding to their activators or inhibitors. In this work, scientists found that ID1 helps maintain cancer stem cells in glioblastoma, making them less susceptible to treatment. Researchers found that when they “turned off” the protein ID1 in lab models and human cells using CRISPR technology or a drug that is traditionally used to treat psychosis and Tourette’s syndrome – pimozide – glioblastoma tumors slowed down. The team also found that turning off the protein altogether helped tumors become less resistant to chemotherapy.Glioblastoma is an aggressive form of brain cancer, representing 15 per cent of all primary brain tumors, and is often difficult to treat. Therapy generally involves the combination of several approaches to control the disease, but there is currently no cure. The diagnoses of the late Tragically Hip singer Gord Downie and U.S. Sen. John McCain have raised the profile of glioblastoma in recent years.Related StoriesNew protein target for deadly ovarian cancerMother calls for protein shake regulation after daughter diesBacteria in the birth canal linked to lower risk of ovarian cancer”The average survival rate for glioblastoma is less than two years and we unfortunately don’t have too many options to offer these patients,” said Dr. Das, who is also a neurosurgeon at St. Michael’s.”Our findings suggest that we may be able to enhance the effectiveness of therapies we already have, such as chemotherapy, as opposed to taking many years to create entirely new therapies.”In lab models, researchers found that inhibiting ID1 slows the progression of tumors in glioblastoma, breast adenocarcinoma and melanoma. In human tissue, they found that the protein caused cells to be more resistant to chemotherapy treatment in glioblastoma. Turning off this protein using the medication pimozide increased overall survival and caused glioblastoma tumors to recur less frequently, progress less and grow more slowly.”Targeting the protein with medication may present a novel and potentially promising strategy for patients with glioblastoma,” Dr. Das said.The next steps for this research, Dr. Das explained, are to look at the development of new inhibiting medications for ID1 and commence a trial to ensure that the targeting is effective. Source:St. Michael’s Hospitallast_img read more


Smart solutions to join carbon fiber reinforced plastics and metal

first_imgTo produce the part, researchers drew on an additive manufacturing technique that uses a laser beam to form components out of a metal powder. The rear-wheel support is connected to the CFRP footboard using a screw system – making it easy to remove and disassemble for maintenance. CFRP recycling—into the battery instead of the garbage Citation: Smart solutions to join carbon fiber reinforced plastics and metal (2019, March 1) retrieved 17 July 2019 from https://phys.org/news/2019-03-smart-solutions-carbon-fiber-plastics.html Whether it is buses, cars, scooters or bicycles, it seems certain that electromobility will power the future. One of the biggest hurdles at the moment, however, is how to increase vehicle range – a challenge that will depend on making vehicles as light as possible. The lighter the vehicle or transporter, the longer the energy storage lasts. In this domain, Carbon Fiber Reinforced Plastics, or CFRP for short, are the material of choice – as strong as steel and yet some eight times lighter, and even three times lighter even than aluminum. The general practice is to manufacture individual components, the vehicle frame for instance, using CFRP, and then join them to the function-bearing metal components using screws or adhesives. In other words, components that connect long expanses and transfer loads can be manufactured using CFRP, while metal is reserved for the functional components and attachment points for the steering mechanism, for example.Weight savings of up to 50 percentNow, researchers from the Fraunhofer Research Institution for Casting, Composite and Processing Technology IGCV at the Technology Center in Augsburg have come up with a variety of innovative new techniques to join conventionally cast components with those made of CFRP. Looking beyond the thoroughly established foundry technology, there is a lot of potential in modern manufacturing techniques such as additive manufacturing and 3-D printing. “We’ve combined the various new joining techniques in an electric scooter demonstrator. The goal is to cut down on the number of mechanical attachment points and simplify the joining process as much as possible,” explains Dr.-Ing. Daniel Günther, who heads the project at Fraunhofer IGCV. “There’s a lot of potential in combining metal and CFRP components, with a potential weight saving of up to 50 percent depending on the part.” The engineering of lightweight vehicles requires manufacturers to combine functional metal components with lightweight, highly durable carbon fiber reinforced plastics. Fraunhofer researchers have developed a variety of solutions for joining such disparate materials – and will be showcasing their technology at this year’s Hannover Messe on April 1-5, 2019 using an e-scooter demonstrator (Hall 17, Booth C24). Smart solutions to join carbon fiber reinforced plastics and metal. Credit: Fraunhofer IGCV Connecting piece prior to lamination, showing the novel pin structure that helps create a positive bond with the CFRP prepreg. Credit: Fraunhofer IGCV This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Explore further Smart use of materials. G= Casting; C= Composite; V= Processing Technology. Credit: Fraunhofer IGCV Provided by Fraunhofer-Gesellschaft Clamping technique to join rear-wheel supportThe rear-wheel support of an electric scooter contains a lot of parts integral to its functioning and, for that reason, it is made out of metal. To make it as lightweight as possible, the research team produced the part out of highly durable steel, optimizing the topology so the material is restricted solely to the places it is needed to support the functioning. Adhesively bonded hybrid steering headThe steering head of the scooter is a hybrid component, with an aluminum base frame linking to the footboard behind and the handlebars at the front.This part of the scooter is full of parts integral to its functioning, with a significant expanse to bridge in-between. Using CFRP parts ensures the necessary rigidity. The two different materials are joined together using adhesive bonding. “In terms of a baseline load, we assumed a person weighing one hundred kilograms performing jumps with the scooter. To support that sort of load using a pure aluminum cast part, you would need a huge amount of material to ensure sufficient rigidity,” says Günther. To manufacture the part, Günther and his team began by analyzing the available installation space. As a rule of thumb, the more room used, the larger the cross-section of the component – and the better its rigidity. The material has to be kept as thin as possible, however, to ensure that the component does not become overly heavy. The solution to this is to use CFRP in combination with cast metal. As a further step, the researchers calculated the load at various points of the component. The splices have been precisely positioned at the points with the least load. Rigidity is guaranteed thanks to the shaping of the CFRP component.’Fork’ system: The joining technology of the futureThe load-bearing capacity and durability of CFRP comes from the fibers contained within it. Here, the main challenge lies in transferring the force acting on a component so it is absorbed by these same fibers. On top of this, engineers need to ensure that any metal parts are as securely attached to the CFRP components as possible, without any gaps or cavities. In response, the researchers have developed a completely new joining technique – best explained by taking a look at the components involved. In the example of the electronic scooter, you have a cylindrical piece connecting to the handlebars, a steel component made using an additive manufacturing technique. The bottom of the component has a plate that works as a base with small pins sticking out from its surface. Researchers then overlay this base plate with the prepregs for the CFRP component, made out of fibers coated with synthetic resin. Afterwards, they apply vacuum and increase the temperature. The resin encloses the carbon fibers, flows downwards and closes the gap with the metal plate, hardening to form an adhesive bond. Here, not only does the resin stick to the plate, the protruding pins are also enveloped and held in place by the fibers. This interlocks the components and supplies a solid bond – without the need for screws or additional adhesives. “The technique is fast, industry-ready and can easily be scaled up for mass production,” says Günther.Fraunhofer Researchers will be showcasing the e-scooter and the joining techniques described in this article at the Hannover Messe from April 1 to 5, 2019 (Hall 17, Booth C24). For anybody interested, there will be the opportunity to take a test drive and find out more about the design and manufacture of the individual components.last_img read more


Talks with govt inconclusive truckers on strike from todayTalks with govt inconclusive

first_img COMMENT July 20, 2018 As talks with the government remained inconclusive till late last night, the truckers under umbrella body AIMTC today went on a nationwide indefinite strike demanding reduction of diesel prices and toll fees. The strike call however has so far remained ineffective, barring a few places, as truckers are hopeful of some solution, according to reports. AIMTC Secretary General Naveen Gupta said that the body decided to go on strike this morning as talks with Finance Minister Piyush Goyal which continued till 1.30 am today remained inconclusive as nothing concrete was being offered.”Gupta said, “today the body is slated to meet ministry officials concerned and earlier, transport minister Nitin Gadkari had sought three months time.”“We are hopeful of some concrete solutions today,” Gupta said. Yesterday, Bal Malkit Singh, Chairman, AIMTC core committee, had pegged the daily loss to truckers at Rs 4,000 crore. Truckers’ key demands include reduction in Central and state taxes by getting diesel under GST ambit so that price of the deregulated commodity can be reduced. AIMTC said it is also against the “flawed and non-transparent” toll collection system that favours road concessioners, and alleged that the time and fuel loss goes up to Rs 1.5 trillion annually on account of this. Truckers are also miffed at high insurance premia and want a reduction in third-party premium, exemption on third-party premia from GST. Apart from this, they are also pressing for exemptions and abolitions in direct taxes, national permits for all buses and trucks.“We are very open to look into all their issues and hope that better sense prevails,” a road ministry official had said yesterday. Established in 1936, the All-India Motor Transport Congress (AIMTC) calls itself the apex body of transporters representing over 93 lakh truckers and around 50 lakh buses, tourist taxi and cab operators. Published on SHARE SHARE EMAIL File Photo   –  The Hindu SHARE strike road transport COMMENTS Trucking industrylast_img read more


Special tanker train reaches droughthit Chennai with water IN PHOTOS

first_imgOther Galleries 6 images Thu, 04 Jul, 2019 Devotees take part in annual Jagannath Rath Yatra| See pics 6 images Tue, 02 Jul, 2019 In Photos: Security personnel conduct route march after clashes in Delhi’s Hauz Qazi 7 images Mon, 01 Jul, 2019 Mayhem of Mumbai rains in photos 3 images Sat, 29 Jun, 2019 Madhya Pradesh politicians talk about need for youth in politicsOther Photogallery CategoriesIndiaMoviesLifestyleTelevisionAdd new comment Your name * E-mail * The content of this field is kept private and will not be shown publicly. Comment *More information about text formatsPlain textNo HTML tags allowed.Web page addresses and e-mail addresses turn into links automatically.Lines and paragraphs break automatically.Set As Featured: Set As Featured647x363: 483×271: 370×208: 170×96: 88×50: Section: PhotoIndiaGallery Image: Image: Credit/Source: REUTERSCaption: A special 50-wagon train, carrying water from Tamil Nadu’s Vellore district, reached Chennai on Friday.Thumb Image: Enable: EnableOrder: 1Image: Credit/Source: Jaison GCaption: Each wagon has capacity to carry 50,000 litres of waterSyndication: SyndicationThumb Image: Enable: EnableOrder: 2Image: Credit/Source: Jaison GCaption: Earlier, Tamil Nadu Chief Minister K Palaniswami announced the state government’s plans to transport 10 million litres of water daily by rail from Jolarpettai to meet the needs of parched Chennai.Syndication: SyndicationThumb Image: Enable: EnableOrder: 3Image: Credit/Source: Jaison GCaption: K Palaniswami said that sum of Rs 65 crore had been allocated for this purpose.Syndication: SyndicationThumb Image: Enable: EnableOrder: 4Image: Credit/Source: Jaison GCaption: The train was flagged off from the Jolarpettai station on the morning of Friday.Syndication: SyndicationThumb Image: Enable: EnableOrder: 5Image: Credit/Source: Jaison GCaption: A trial run was conducted successfully on Wednesday from Mettu Sakrakuppam pumping zone to filling point at Jolarpettai railway station.Syndication: SyndicationThumb Image: Enable: EnableOrder: 6Image: Credit/Source: Jaison GCaption: Local bodies minister SP Velumani participated in the function when the wagon arrived at the station.Syndication: SyndicationThumb Image: Enable: EnableOrder: 7Tags: ChennaiDroughtTrainSource type: photogalleryShort description: The special water train that reached Chennai, Tamil Nadu on Friday was was flagged off from the Jolarpettai station on Friday morning.Preview_unique_id: preview_5d28a431b99681562944561_1567893_editCommentContent Publish date: Friday, July 12, 2019 – 20:30Story Extra Data: eyJzZWN0aW9uIjpbIjEyMDY1NzgiLCIxMjA4NTIxIl0sImNhdGVnb3J5IjpudWxsLCJzdWJfY2F0ZWdvcnkiOm51bGwsInN1Yl9zdWJfY2F0ZWdvcnkiOm51bGwsInN1Yl9zdWJfc3ViX2NhdGVnb3J5IjpudWxsLCJwcmltYXJ5X2NhdGVnb3J5IjoiMTIwNjU3OCJ9770x433: Short Headline: Special tanker train reaches drought-hit Chennai with water: IN PHOTOSApp headline: Special tanker train reaches drought-hit Chennai with water: IN PHOTOS1200x675:last_img read more