Entomologists discover first instance of intact neurons without nucleus in fairy wasps

first_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Flight Artists film smallest insect in flight More information: Arthropod Structure & Development, Volume 41, Issue 1, January 2012, Pages 29-34. doi:10.1016/j.asd.2011.09.001 A cell’s nucleus is of course, usually pretty important, it’s where the DNA is generally stored after all. It’s also usually the part of the cell that runs things, like causing a replenishment of proteins to keep cells alive, etc. This of course got the researchers to wondering how an insect could survive if most of its neurons had no nucleus.The secret, the team writes, lies in the fact that the insect is so small, that neurons (with nuclei intact) that develop during the pupa stage apparently make enough protein to last the full five days of its adulthood, so, not needing them any longer, all but a few hundred of the nuclei are destroyed by bursting, making the cell smaller and saving room for other more important cells. The team notes that this is the first recorded instance of neurons existing in the wild without benefit of nuclei.The team also found that the fairy wasp has one of the smallest nervous systems around, with just 7,400 neurons, but can still fly, search for food and figure out where to lay it’s eggs; which is inside the eggs of another tiny insect, the thrips, which itself is no bigger than a millimeter in length. It manages this feat by cramming virtually all of its nervous system into just its head, hence the need for downsizing the number of neurons and reducing cell size wherever possible.The fairy wasp also has other adaptations that allow it to survive in its small state. It has a reduced wing surface for example which means wings that amount to little more than bare strands as opposed to the rather broad based flappers other larger insects sport, just enough to allow it to coast along with moving air. Citation: Entomologists discover first instance of intact neurons without nucleus – in fairy wasps (2011, December 1) retrieved 18 August 2019 from https://phys.org/news/2011-12-entomologists-instance-intact-neurons-nucleus.htmlcenter_img © 2011 PhysOrg.com Explore further Fairy wasps are really tiny; so tiny, they can barely be seen with the naked eye. They’re so tiny that they’re the smallest organism when shown on a slide alongside an amoeba and a Paramecium. And because of this, a group of researchers from Moscow State University began wondering how a neurological system in such a tiny insect could work at all. As it turns out, as they describe in their paper published in Science Direct, the fairy wasp (M.mymaripenne), the third smallest of all insects, has a lot of neurons without any nucleus.last_img read more


Light field microscopy for whole brain activity maps

first_img One of the early pioneers of LFM was Marc Levoy, who many folks may have heard of due to his groundbreaking work at Google. His many projects include co-designing their book scanner, launching Street View, and contributions Google glass. Together with his collaborators, Marc also refined the techniques that led to the imaging system used in the popular Lytro camera, which like LFM can be refocussed after-the-fact to different parts of an image. To create the LFM they placed a microlens array beyond the specimen at the intermediate image plane of a conventional microscope. Different points on the sample are then recorded in separate small images on a light field plane further above the sample. Deconvolution techniques can then used to build up whole images.While the LFM has been used before for in-vitro imaging, Ed’s new work represents the first time that spatial resolutions comparable to the groundbreaking zebrafish brain activity maps (courtesy of Misha Ahrens) have been presented. I asked Ed how his new work in imaging the entire c. elegans worm compares with the light sheet methods used by Ahrens and company. He stressed that eliminating the physical component, (the actual scan) is the key to the superb temporal resolution now possible, and that the deconvolution algorithms yield the improved spatial resolution. While the zebrafish results were acquired in a volume 800x600x200 microns per side, with an impressive lateral resolution of 0.65 um, the refresh rate was a relatively slow 1.3 seconds. With Boyden’s LFM, the imaging volume used was slightly smaller (~350 μm x 350 μm x 30 μm) although that is fine here because basically, the entire nervous system of the worm, in fact most of its body, could fit in that volume. The resolution was a respectable ~1.4μm in the lateral dimension and 2.6μm in the axial, still good enough for single neuron precision. The impressive thing here though is the whole volume image rate—up to 50 hz. That is fast enough to shift the temporal resolution problem away from the hardware, and put it back in the laps of the chemists that make the dyes or protein sensors used for imaging. Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: Light field microscopy for whole brain activity maps (2014, January 29) retrieved 18 August 2019 from https://phys.org/news/2014-01-field-microscopy-brain.html Journal information: arXiv At the end of the day these mapping techniques are really only as useful as the questions one can ask, and answer, using them. Last year’s fascinating images of a zebrafish watching its lunch swim by as a cerebral doppelganger of fish activity percolated eerily through its own brain was proof enough of this. Ed and his group were already able to image the complete set of head ganglia neurons in the worm at the same time selected ventral cord control units were imaged, not a bad start. Not having any real experience myself, as far as how these techniques are actually implemented into the experimental workflow, I asked neurophysiologist David Schoppik to comment here. In his words:”This work from the Vaziri and Boyden laboratories is both important and exciting, and is a nice complement to ongoing work in the Levoy lab (Broxton et. al., 2013). While a light-field microscope can acquire data breathtakingly quickly, processing times of 20-90 minutes/frame (i.e. weeks of processing to analyze a couple minutes of acquired data) limits its applicability. As hardware and algorithms mature, this is sure to improve. Perhaps most excitingly, as the next generation of genetically-encoded voltage sensors comes online, light-field microscopy unique holds the promise of acquisition of large volumes with the speed necessary to capture membrane potential dynamics.”To David’s point, we are already beginning to see some of these next generation voltage sensors take shape. Intriguing work on multi-state “Flash Memory” sensors that can be toggled on and off by different wavelengths of light have just been published. Some of the fancier techniques, like direct genetic encoding, enable the sensor to be targeted to just a small number of specific cells. This is crucial so that the total number of signal producers in the field of view is not so large that everything is bright. At the same time however, as we have learned using techniques like Brainbow II, if you only have labelled synapses, you don’t have the whole picture. Glia, blood vessels, and organelles are all critical pieces of the puzzle.However now, we are beginning to understand that much of the larger activity of the nervous system, particularly at the periphery, is not something we can readily comprehend in isolation from the immediate tissue in which it embeds. Something as simple as tactile sensing in the worm, whether by raw nerve ending or whatever version of a vibratory corpuscular sensor a worm might possess, are really larger chemo-mechanical issues that extend beyond nerve membranes. Imaging the entire body of the worm, down to the level of movements of cell organelles should give a fuller picture of integrated activity beyond transient calcium or voltage spikes.If functions like adaptation and memory, as many now believe, involve structurally observable change—actual motions by and within cells—then perhaps these slower dynamics will come to be appreciated on par with the faster spikes associated more with direct signalling. The previously unimagined abilities of cells (including neurons) to target and exchange mitochondria, for example, might be imaged in worms and correlated directly to spiking activity. It may be a slight digression from microscopy techniques, but if we consider an extreme case of organelle transport, we might have some guidance for what to look for in new experiments. The 10-meter long motor axons of the blue whale, for example, need to provide fresh organelles that offer proteins and power to the end effectors where they are needed. However doing this on any kind of timescale relevant to spikes or synaptic modifications is not just difficult, it is impossible. Slow phase axonal transport would take decades to reach their muscle target points, while even the fast component pool (perhaps several mm/day) would still take months. Furthermore, consider here that during the growth phase, the whale axons tethered to the fluke region are being pulled aft at the astounding rate of 3cm per DAY. That imposes a huge “volume debt” that must be satisfied by some source of cellular materials.The point of this diversion is that if in larger creatures, neurons are materially isolated from their targets on the timescales of electrical activity, than local tissue interactions, like sharing mitochondria and other packages of genetic information, most be significant. For now, the humble worm, together with these new LFM methods offers an ideal platform to further probe these kinds of activities from the molecular to tissue level. As they give way to in vivo imaging of larger brains, nerves, and bodies, we should have a clearer picture of what we might count as “activity” in the full functional map of a calculating organism. Capturing brain activity with sculpted light © 2014 Phys.org More information: Simultaneous whole-animal 3D-imaging of neuronal activity using light field microscopy, arXiv:1401.5333 [physics.optics] arxiv.org/abs/1401.5333Abstract3D functional imaging of neuronal activity in entire organisms at single cell level and physiologically relevant time scales faces major obstacles due to trade-offs between the size of the imaged volumes, and spatial and temporal resolution. Here, using light-field microscopy in combination with 3D deconvolution, we demonstrate intrinsically simultaneous volumetric functional imaging of neuronal population activity at single neuron resolution for an entire organism, the nematode Caenorhabditis elegans. The simplicity of our technique and possibility of the integration into epi-fluoresence microscopes makes it an attractive tool for high-speed volumetric calcium imaging. (Phys.org) —Advances in light-sheet microscopy have led to impressive images and videos of the brain in action. With this technique, a plane of light is scanned through the sample to excite fluorescent calcium sensors which proxy neural activity. While the transparent head of a baby zebrafish, or even the whole body of a tiny worm can now be mapped with impressive lateral resolution, the temporal resolution is still limited by the need for the scanning. A potentially much more powerful technique—light field microscopy (LFM)—gets rid of the moving parts and can therefore create volumetric images in a fraction of the time. Ed Boyden and his collaborators have now tuned these methods to create the first “functional LFM images” of the brain. Their results have just been published to the Arxiv preprint server. C. elegans. Credit: home.physics.ucla.edulast_img read more


CERN upgrade to require removing thousands of old unused cables

first_img Citation: CERN upgrade to require removing thousands of old unused cables (2016, January 28) retrieved 18 August 2019 from https://phys.org/news/2016-01-cern-require-thousands-unused-cables.html The ATLAS detector. Credit: Maximilien Brice/CERN Anyone who has ever looked into a cable closet knows that after some time has passed, it comes to resemble a rat’s nest. The ones’ at CERN have been growing since approximately 1954 when CERN was first established. Since that time, workers have been adding new cable with each upgrade to provide for new services. Unfortunately, they were not removing old cables as they became obsolete. That has led to a situation where there is no more room for putting in the new cables required for the LHC Injectors Upgrade Project scheduled for 2019.Complicating the removal process is the difficulty in ascertaining which cables need to be removed (most of them are part of safety and control systems)—some of which wind their way through other equipment and systems areas and stretch to over half a football field in length. Pulling the wrong cable could be disastrous, because it could cause the collider to shut down, wasting valuable up-time. To handle the task, a team of 60 workers has been assembled and trained—their immediate task is to identify which cables to pull—they are comparing entries in a database of all installed cables with what they actually see in the field, and then updating the database to reflect the new reality—the team has thus far found an error rate of approximately 2 percent. The cables cannot be pulled, of course, during the time when the accelerator is in operation—that will have to wait for the annual winter maintenance shutdown (technical stop).The team reports that in some areas, some cables have already been removed, approximately 2,700 of them, but they have also identified approximately 3,000 cables in each injector which still need to come out, adding up to 9,000 in all. Because of the sheer number of cables, the team will not be able to remove them all during one technical stop, they will have work on them every year until they get the job done, which they estimate will be in 2020—just in time for the major 2019 upgrade to take place. Explore further (Phys.org)—As if upgrading one of the most complicated pieces of machinery in the world three years from now is not difficult enough, workers on the CERN project are also going to have to remove, according to Motherboard, approximately 9,000 old, unused cables.center_img © 2016 Phys.org Nano-coating makes coaxial cables lighter This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more


Historys angels in the Capital

first_imgFamous for his strong expressionist visual language, Vikash Kalra has already conducted five solo exhibitions in Delhi and elsewhere. The present solo show, Angels of History is presented by Siddharth Tagore of Art Konsult, New Delhi and is curated by noted art critic and curator, JohnyML.Vikash Kalra, a young artist whose works have already become an integral part of most of the eminent art collections in India and abroad, is known as a ‘contemporary Souza’. Inspired by the works of Pablo Picasso and Souza, this self taught artist worked his ways through the dense forest of Indian art scene and established a space of his own. With a decade long career to claim for himself, Vikash has an interesting life which is worth following. Also Read – ‘Playing Jojo was emotionally exhausting’Born in Delhi and educated in Delhi University, Vikash had donned many hats during his growing up years. A book on Picasso found amongst the second hand books took Vikash to a new realm of experience. As if touched by a spiritual vision, he did 2000 drawings in a week’s time on magazine pages. It was a life changing experience. Vikash left everything behind to become an artist and the decision proved to be right as his talent was recognized by galleries and art collectors. Also Read – Leslie doing new comedy special with Netflix‘Looking at the paintings of Vikash Kalra, which is prolific in output as he works like a possessed man day in and day out, one could say for sure that it is neither market nor critique on his works that sets his creative spirit ringing. There is something that is beyond all the materialistic considerations that makes this artist to work through conducive and difficult times. Perhaps, in Kalra’s own words, there is no time which is difficult for an artist,’ writes JohnyML, the curator of the show. An ardent collector of music and musical instruments, Vikash spends most of his time in his studios, painting, sculpting and making music of his liking. A documentary on his life has been produced by noted art critic, Vinod Bharadwaj. Vikash creative life so far has been the life of a wandering minstrel; the one who wanders through the streets of art. Angels of History places him along with the major contemporary artists in India.DETAILAt: Visual art Gallery, India Habitat Centre On Till: 19 April (11 am – 8 pm), Show will continue from 20 April to 4 May at Art Konsult, Lado SaraiTHE URBAN REALITY CHECKUrban life all around comes with a lot of pros and cons. Social satire has been around since people have been around. Cities have everything in king size, both the beauty and the ugliness. City life is rich in poetic and marvelous subjects. We are enveloped and steeped as though in an atmosphere of the marvelous; but we do not notice it. In Urban Realities both of the artists presents a glimpse of the trepidations, congruence and the conflicts of  urban life  in different forms through different mediums. Forchino chooses to create figures and scenes that give a comical twist to mundane characters. They are typically humorous subjects such as a family leaving on vacation in an overloaded car with flat tires etc. While Hemant Puri uses exploits of urban life and the contrast of traversing from semi urban to urban life in which space which is basic to every object plays a vital role.DETAILAt: Gallery Art Positive , Lado Sarai On Till: 10 April – 10 May (11am – 7 pm)FOR SOME TRANQUILITYThe group art show Tranquility at Shree Yash Art Gallery, New Delhi encompasses various eminent artists and brings them together by captivating a vast range of moods and moments in their respective walks of life. Participating artists include Madan Lal, Nand Lal Thakur, S.D.Shrotriya, R.C Bhawsar, Prithvi Soni, Harish Kumar, Manjit Soni and Savita Agrawal. The show is putting on display the  picturesque landscapes of Shrotriya, the true to life depictions ofBhawsar, the well known Prithvi Soni’s vibrant coloured Rajasthani folk classics, Nand Thakur’s myriad abstract forms, Harish Kumar whose art work valuation is steeping up due to sheer indian content. Viewers have by now been well acquainted with hues of contemporary works of Madan Lal. Lastly, the traditional art works of Savita Agrawal, Director and curator, Shree Yash Art Gallery.  The show is aptly titled Tranquility as it allows the artists to freely express their art forms with such dexterity and proficiency that the outcome has to be nothing but tranquil.DETAILAt: Shree Yash Art Gallery, Green Park Main On Till: 15 – 30 April (11 am – 7 pm)last_img read more


19 killed in South Yemen clashes

first_imgAt least 19 people have been killed in Saudi-led coalition air strikes and clashes between pro-government forces and rebels in Yemen’s south, military sources said.The air strikes took place late Friday and targeted two rebel vehicles on a road linking the central province of Ibb province to Daleh province further south, the sources said. Forces loyal to Gulf-backed Prez Abedrabbo Mansour Hadi recaptured Daleh and four other southern provinces in July.last_img


Peace will be restored at Amdanga assures Abhishek

first_imgKolkata: Abhishek Banerjee, All India Trinamool Youth Congress president and party MP, on Thursday urged the people to work together to restore peace at Amdanga.Addressing a party rally at Amdanga on Thursday afternoon, Banerjee said he would ensure that peace is restored in the area. “I will personally look after Amdanga and I assure you that peace will be restored here,” he said.Coming down heavily on CPI(M), Banerjee alleged that the party was unnecessarily trying to create trouble in the area, just to stall the development work taken up by Mamata Banerjee. “CPI(M) has joined hands with Congress and BJP to destabilise the area. But we cannot allow that to happen. Rest assured, peace will be restored soon,” he said. Also Read – Rain batters Kolkata, cripples normal lifeHe said in 2016, CPI(M) had formed an alliance with Congress and the result was disastrous. “The party has been washed away. But they have not learned anything from the past and are now trying to create trouble with the help of Congress and BJP,” Banerjee said. He said that during the Maheshtala by-election, central forces were there and CPI(M) had alliance with Congress, but despite that Trinamool Congress candidate Dulal Das had won by 65,000 votes. Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killedHe said Trinamool Congress does not believe in bloodshed. “We believe in peace and development. In the past seven years, the development that has taken place is Bengal is remarkable. We will not allow anyone to stall that development,” he said.Banerjee said CPI(M) had unleashed a reign of terror in Bengal for 34 years, during which thousands of Trinamool supporters had been killed. “If Trinamool had the intention of taking revenge, we could have taken law into our own hands after winning on may 20, 2011. But Mamata Banerjee asked us not to take revenge and we followed her instructions. We believe in democracy and peace,” Banerjee said.last_img read more


Know who is most likely to help you at office

first_imgShedding new light on how status affects workplace relationships, a new study has found that workers are most likely to help colleagues who are moderately distant from themselves in status — both above and below them.“The sweet spot for helping seems to be those who are moderately distant from you in status,” said study co-author Robert Lount, associate professor of management and human resources at The Ohio State University in the US.The study did not examine why colleagues who were moderately distant in status were most likely to help each other. But it may be related to how workers perceive their own status within the company, lead researcher Sarah Doyle from The Ohio State University noted.  Also Read – ‘Playing Jojo was emotionally exhausting’“Someone near you in status poses more of a threat” Doyle said. Those who are far above or below you in status could require a lot more time and effort to help, which could hurt your own job performance.Those colleagues who are moderately distant do not pose much of a threat and offer the best opportunity for workers to demonstrate their willingness to cooperate with their teammates. The findings appeared online in the journal Academy of Management Discoveries. The researchers conducted two separate studies — one in a real workplace  and both reached similar conclusions. Also Read – Leslie doing new comedy special with NetflixIn the first study, 267 undergraduate students read a work scenario in which they imagined they were part of a 15-person work group in a large sales organisation.Participants were told that one of their group members was close to securing a large account, but was running short on time. The participants were asked if they would be willing to provide help, knowing that helping was optional. Results showed that participants were most likely to say they would help a team member who was moderately different from them in status.The real-world study was conducted in a large customer call centre. For the study, 170 employees completed an online survey asking a variety of questions.  Included was a question asking each employee to list co-workers who regularly came to them for help and co-workers whom they regularly went to seek help.In this real-world office, the finding of the first study was confirmed. Workers were most helpful to teammates who were just the right distance away as far as status goes —not too close and not too far. The findings might be useful when assigning people to train new employees.last_img read more


Chronicle of Durga Puja released to give readers a peek into its

first_imgKolkata: Durgadalil, a book comprising a through documentation of Durga Puja, was released in the city on Sunday.The book, edited by Samrat Chattopadhyay, will be made into a documentary film with the demand of making Durga Puja a national festival. The work for the documentary film will start on January 6, 2019, with a programme at Uttam Mancha.Through this monumental work, the demand to make Durga Puja a national festival will be raised. It may be mentioned that National Geographic channel will cover Durga Puja in Kolkata for the first time. The channel covers Ganesh Chaturthi in Maharastra and Kumbh Mela. Also Read – Rain batters Kolkata, cripples normal lifeThe book is a research work on 400 years of Durga Puja. It deals with the frequently asked questions like where Durga Puja started in undivided Bengal, or whether it began in Taherpur in Rajsahi (now in Bangladesh), in Malda or South Dinajpur.It also answers whether Raja Kangsha Narayan, Bhabananda Mazumdar or Raja Jagat Narayan was the protagonist of the Puja. History scholars Haripada Bhowmick and Professor Sandip Kumar Dawn have dealt with the subject, spreading over a large span of time from the Moghul period to the present day. Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killedNoted photographer Atanu Pal and well known art collector Ganesh Pratap Singh have provided photographs which have increased the value of the priceless collection.Elderly people as well as many contemporary celebrities have narrated Durga Puja stories that are related to their localities, in the book. In erstwhile Kolkata, Pujas were held in the houses of aristocrats, beside the community Pujas. There were no sponsors and the Pujas were organised by collecting subscription from the local people. After the Pujas, musical soirees were held, in which noted vocalists and musicians took part.While Nabanita Dev Sen has narrated stories that are related to the areas surrounding Hindusthan Road in South Kolkata where she had spent her childhood and has plenty of childhood memories, elocutionist Jagannath Basu has told about his experiences in North Kolkata.Well known football organiser of the 70s, Ajay Srimani, has spoken about Durga Puja in his house and neighbouhood.Actors Abir Chattopadhyay and Kaninika Bandyopadhyay have narrated their childhood memories, along with cricketer Jhulan Goswami and former footballer Achintya Belel.last_img read more


CCD robbery in Salt Lake Three arrested including exemployee

first_imgKolkata: Three youths have been arrested by Bidhannagar North Police Station for committing robbery at a cafe Coffee Day (CCD) outlet in Salt Lake. According to police, one of the accused was an employee of the same outlet. As his one-and-a-half month salary was due, he planned the robbery to get his due money.During investigation, the sleuths had found CCTV footages where three suspected persons were seen. When the CCD employees were shown the footage, they identified one Sankar Das, who was an employee there a few months ago. Later, police obtained Das’ mobile number and started the tracking process. As his mobile phone was switched off, the sleuths could not track his tower location. On Saturday night, Das’ tower location popped up on the screen as soon he switched on his mobile phone. The location of his phone was in Gaighata. Without wasting time, a team comprising members from the Detective Department (DD) and Bidhannagar North Police Station went to Dhakuria in Gaighata and detained Das. Later, Das told police his two friends identified as Biltu Sarkar and Surajit Roy had helped him to commit the crime. The other two youths were also detained from Gaighata area. During interrogation, they admitted to their crime and were arrested on Sunday morning. According to the sources, Das admitted to have come on foot and waited for the shop to open. As Das was an employee, he knew that only one person would be there in the first few hours. As per the plan as soon as the shop opened, Das sent Sarkar and Roy inside to overpower Suvankar Ghosh, the employee who opened the café on that day. Das entered the shop after Ghosh was tied up and looted the cash present. All of them fled on foot. The sleuths have recovered the bags, wearing appeals and mobile phones of the trio. On October 29 morning around 10:30 am, the CCD outlet at AD block was robbed. The trio approximately took Rs 18,000 from the cash box and fled.last_img read more


Bengal lawyers end monthlong cease work

first_imgKolkata: The ongoing cease work of the lawyers in the state for over a month was lifted on Friday, with the state Bar Council appealing to the lawyers to postpone their movement and commence their work. Normal work will resume from Saturday. “We have decided to postpone the strike till September 2, keeping in mind the harassment of the people. All steps have been taken and a resolution that was taken at the Council’s meeting today (Friday) has also been put up in the form of a notification. The lawyers are joining work from Saturday,” said Baiswanor Chatterjee, member of the working committee of the Bar Council. A notification urging the lawyers to join work has also been published. Also Read – Rs 13,000 crore investment to provide 2 lakh jobs: MamataThe common people seeking justice had to face a lot of problems because of the cease work and people coming to Calcutta High Court and the lower courts from far-flung districts seeking justice have been returning home disappointed. There were indications earlier that the cease work will be withdrawn soon after the election process. A major clash took place between the lawyers and staff of Howrah Municipal Corporation (HMC) over vehicle parking at Howrah Court area on April 24. Some lawyers were injured in the clash after the police intervened, following which the lawyers called for cease work alleging police excess. The lawyers in the other courts also extended solidarity to the movement and it spread to all courts across the state. “We are still sticking to our demand that those responsible for the attack on the lawyers should be punished. However, the strike has been postponed considering the problems faced by the common people,” a member of West Bengal Bar Association said.last_img read more


Why grief is bad for the heart

first_imgSleep disturbance among people grieving the recent loss of a spouse may put them at increased risk for cardiovascular illness and death, a study has warned. Recently widowed people are more likely to suffer from sleep disturbances, such as insomnia, that may lead to increased levels of inflammation in the body. Higher levels of inflammation may in turn increase risk for heart diseases, showed the findings published in the journal Psychosomatic Medicine. Also Read – Add new books to your shelfThe study found that the link between sleep disturbances and inflammation was two to three times higher for the bereaved spouses. “The death of a spouse is an acutely stressful event and they have to adapt to living without the support of the spouse,” said Diana Chirinos from Northwestern University Feinberg School of Medicine in Chicago, US. “Add sleep disturbance to their already stressful situation and you double the stressor. As a result, their immune system is more overactivated,” Chirinos said. Also Read – Over 2 hours screen time daily will make your kids impulsiveThe study included 101 people with an average age of 67. Half were bereaved (identified through obituaries), and the rest were included in a control group. The researchers compared the self-reported sleep habits of recently widowed people to the control group. Both the groups had sleep disturbances. The researchers found that the link between sleep disturbances and inflammation was two to three times higher for the bereaved spouses. Inflammation was measured by the level of proinflammatory cytokines, which are designed to be short-term fighters of disease but are linked to long-term risk for health problems including cardiovascular disease. Bereaved individuals are more susceptible to the negative health effects of poor sleep, the study said.last_img read more


Calcutta University adopts online entrance test for PG courses

first_imgKolkata: Calcutta University on Monday opted for the online entrance examination for all Post Graduation (PG) courses. “The way the admission process has been made online, Calcutta University will conduct the PG entrance examinations online likewise. The decision has been made for the sake of modernisation, transparency and saving time,” Vice Chancellor Sonali Chakravarti Banerjee said. She said that CU is the first university to introduce this modern way of conducting the entrance test. Also Read – Rs 13,000 crore investment to provide 2 lakh jobs: Mamata Starting this year, the entrance for all the 66 department teaching PG courses in the 162-year-old University and other CU affiliated colleges will now be conducted online. The students will appear for the examinations in specific examination centres allotted by the university. Talking about the final examinations of PG examinations, the VC said for the next academic year, the university will also think about conducting the examinations away from the home centre. For instance, PG students studying in a particular college will have to write their exam in a different centre in order to maintain transparency. “Calcutta University is trying to strengthen the examination system by making it fair and following a path of discipline,” Chakravarti added.last_img read more


Big Trouble in Little China announced as a Sequel not a Remake

first_imgJohn Carpenter fans around the globe are watching closely as news unravels on the fate of an alleged remake of the 1986 cult classic Big Trouble in Little China. Since 2015, it has been announced that a reboot was in the making, with the main role given to Dwayne “The Rock” Johnson ― a wrestler-turned-actor, and star of the Fast and Furious franchise.For those unfamiliar, Big Trouble in Little China is one of the all-time classics of the 1980s comedy/action/fantasy genre. It involves a highly reluctant trucker named Jack Burton, who ends up fighting supernatural creatures in the Chinatown underworld in an effort to save his friend’s fiance from an ancient sorcerer who attempts to sacrifice her to the gods.Dwayne Johnson. Photo by Eva Rinaldi CC BY-SA 2.0It is as weird as it sounds, and even though it was a box-office flop, the film has earned a loyal cult following over the years. The movie summarized the entire decade into one hilarious, over-the-top, trashy flick, with Kurt Russell in his natural state, playing a laid-back trucker who is also handy with a gun.However, even though the next feature was repeatedly confirmed as a remake, it appears as though the creators have decided to turn it into a sequel.Kurt Russell in a 1974 publicity photo.Hiram Garcia, who will produce this next installment told Collider on August 27, 2018:“You can’t remake a classic like that, so what we’re planning to do is we’re going to continue the story. We’re going to continue the universe of Big Trouble in Little China. Everything that happened in the original exists and is standalone and I think there’s only one person that could ever play Jack Burton, so Dwayne would never try and play that character. So we are just having a lot of fun.”Apparently, this plot twist regarding the production sparked further intrigue in an already controversial project.Kurt Russell on the set of The Thing. Photo by Sunset Boulevard/Corbis via Getty ImagesSince the director of horror classics such as The Thing and Halloween has garnered a great fan base over the years, it is understandable that the sequel to one of the most iconic movies of the 1980s has prompted a backlash from fans who believe that such an effort is unnecessary and could only spoil the original.Aware of this, the producers, headed by Dwayne Johnson himself, made several attempts to appease the audience ― some of which backfired. In the early days of pre-production, the actor claimed that he had contacted Carpenter, inviting him in on the project.John Carpenter at a signing in Chicago, 2014. Photo by GabboT CC BY-SA 2.0The famous director denied any such contact. Regarding Johnson’s previous statement, Carpenter told Screen Rant in 2016:“No. No one’s talked to me about it. Haven’t heard a thing!”Of course, this only further infuriated hardcore fans. Johnson added that Big Trouble in Little China is among his favorite movies of all time, promising to do justice to the original movie. But the audience remains more polarized than ever.Actor James Hong with a copy of Big Trouble in Little China. Photo by Carter McKendry CC BY 2.0Apart from Johnson and Garcia, who is also credited as one of the producers of the project, the creative team includes Ashley Miller and Zack Stentz, the screenwriters behind X-Men: First Class.Since news of the sequel surfaced, fans are getting more and more restless. Still, it appears as though everyone agrees that a continuation of the story is a better solution than a simple remake, as remakes often mistreat the original film, or simply fail to recreate the charm and magic of its predecessor.Jack Burton from Big Trouble in Little China Cosplay at Wizard World Chicago 2011. Photo by GabboT – 27 CC BY-SA 2.0Still, a sequel raises numerous other questions, like how will it be connected to the original, or in which timeline will the story occur? Since Johnson won’t be playing Burton, will Kurt Russell perhaps reprise his role?Read another story from us: Top Gun 2 Filming on a Real Aircraft CarrierWe hope to find all this out soon, as this intriguing project sure seems to have garnered large interest, despite the fact that the film is still in its developmental phase and a lot more could change before its release.Nikola Budanovic is a freelance journalist who has worked for various media outlets such as Vice, War History Online, The Vintage News, and Taste of Cinema. His main areas of interest are history, particularly military history, literature and film.last_img read more


Nostalgia for a Bygone Era Brings Guys and Dolls Back to the

first_imgSome movies are timeless, others stuck in time. That’s not always a bad thing, though. Guys and Dolls is a picturesque reminder of decades gone by. Adapted from short stories by Damon Runyon written in the 1920 and ‘30s, the now-musical was turned into a visual spectacle through the compositions of Frank Loesser (“Baby, It’s Cold Outside”) alongside a script by Jo Swerling (The Pride of the Yankees, It’s a Wonderful Life) and Abe Burrows (stage adaptation of How to Succeed In Business Without Really Trying).Guys and Dolls, Libretto and Vocal book, printed by Music Theatre International, 1978. This book was rented out to actors and actresses in the play. Photo by Goldenrowley CC BY-SA 3.0As a play, Guys and Dolls hit Broadway in 1950 and was immortalized on the silver screen in 1955, when some of Hollywood’s most celebrated actors painted an iconic picture of the age.A high school production of Guys and Dolls.Catchy hits like “Luck Be a Lady” and “Sit Down, You’re Rocking the Boat” — never mind the eponymous “Guys and Dolls” — will forever get theater lovers and classic film buffs alike ready to dive back into the Twenties and Thirties. Check out some the most common slang from the era here:Guys and Doll’s nostalgia is transparent. The Eastmancolor visuals make the picture undeniably Old Hollywood, and Jean Simmons and Vivian Blaine’s snarky accents bring viewers back to the post-war years, if not earlier.Vivian Blaine in ‘Something for the Boys’ trailer (cropped screenshot)Even though the film is set during the Depression, the men look striking in handsome pinstripe suits and the women, dolled up (if you’ll forgive the pun), command each scene with vintage fashions. Though Marlon Brando and Frank Sinatra, playing opposite Simmons and Blaine, melt hearts with their sultry tones (okay, maybe Sinatra more than Brando) and equally sultry looks to this day, a remake is officially in the works.The performance of Marlon Brando (shown here much earlier in his career) as Colonel Walter E. Kurtz was critically acclaimedTriStar has successfully obtained the rights to the original Runyon short stories, Loesser’s musical score, and the Samuel Goldwyn Company’s go-ahead for the modern remake. With the full trifecta of power behind them, we can only hope that one of the film industry’s biggest picture houses will do the beloved classic some justice.According to the Hollywood Reporter, it will be produced by John Goldwyn (Dexter, I’m Not There) and Marc Toberoff (I Spy), with Meyer Gottlieb (The Secret Life of Walter Mitty, Master and Commander: The Far Side of the World) as executive producer.Their work will be cut out for them. Musical fans, sometimes dedicated at cult-like levels, are already hard to please. The next few years will be even more challenging for purists as several other musicals await a modern reenactment. Cats comes out Christmas 2019 with an impressively extensive all-star cast, Steven Spielberg’s take on West Side Story is awaits a release date, and Wicked is slated for 2021.Lizbeth Webb as Sarah Brown in the original London production of ‘Guys And Dolls’ at The Coliseum Theatre, 1953It’s unsure when the Guys and Dolls remake will be released, but it’s more than likely that it will be a contender for that year’s Oscars. The original musical won five Tony Awards upon its premiere in 1950 and another four after its revival in 1992. The 1955 film was nominated for four Oscars and won two Golden Globe Awards.Read another story from us: Lethal Weapon 5 May Be Moving ForwardOklahoma! beat out Guys and Dolls in the 28th Academy Awards for Best Scoring of a Musical Picture, so superstitious fans will have to keep their fingers crossed that its remake isn’t in the works in the next couple years.last_img read more


Tom Brady commercial making fun of Deflategate is absolutely hilarious

first_imgThe Deflategate controversy involving Tom Brady will go down as the most drawn out, ridiculous, off-field controversy in the history of sports. The nearly two-year dilemma, revolving around deflated footballs in the 2015 AFC Championship game against the Colts, included federal court appeals that nearly reached the doorstep of the U.S. Supreme Court.During the entire process Brady was deadly serious about defending himself against what he perceived to be an assault on his reputation. For “Tom Terrific”, it was not a laughing matter….until now.Brady, who doesn’t do many commercials, just released one for an annual Foot Locker sale, the premise of which is two kids sitting down at a diner where Brady is seated, where they wonder aloud how the sale can be so great year after year. Something must be up.Brady goes off on the two kids in an aggressively defensive manner, irrationally relating the kids’ suspicions to his own Deflategate controversy. He eventually angrily storms out of the diner. Advertisement Brady kills it and is absolutely hilarious. Props to Tom for poking fun at himself over the controversy. The spot works on every level.Here’s the video:last_img read more


VIDEO Putin meets with Khabib says he was provoked into UFC 229

first_imgAfter his huge UFC 229 win over Conor McGregor and the insane post fight riot that followed, Khabib Nurmagomedov made his way to the Kremlin to meet with Russian “President” Vladimir Putin for a photo op and congratulations.Putin congratulated Khabib on the win and also asked his dad – who said there would be hell to pay for his actions – to cut Khabib some slack. Putie also said he believes that Khabib was provoked into leaving the ring to fight a heckling McGregor teammate, so it was justified.Unlike American sports teams opting out of a White House visit, in Russia you show up or end up in a ditch or poisoned. Watch Putin get his paws into this PR opportunity.last_img read more


Jogger Who Killed Mountain Lion with Bare Hands Gives Details of Horrific

first_imgLast week, a jogger in Colorado had has his run interrupted when he was attacked from behind by a mountain lion in Horsetooth Mountain Park near Fort Collins. Facing the life and death struggle, the man choked out and killed the big cat with his bare hands to save his own life.The identity of the jogger was previously unknown, but yesterday 31-year-old Travis Kauffman came forward as the man from the encounter and told the incredible story of how his leisurely run in the park quickly turned into a fight for his life with a wild animal intent on killing him.He sustained serious lacerations from the clawing and 17 stitches to the face.while the lion was trying to maul him, but it sure beats the alternative.last_img read more


How This CEO Went From 400 Different Passwords to Just One

first_img Register Now » August 28, 2014 4 min read When Heidi Ganahl founded the first Camp Bow Wow in Denver, Colorado in December of 2000, most people had never heard of doggie day care or upscale boarding. The concept took off more quickly than even she imagined, and she now has 122 franchises with 23 more locations in the pipeline across 40 states.Twenty-five employees (and their dogs) work in the Camp Bow Wow headquarters in Broomfield, Colorado along with 3,000 other employees in the franchises. Ganahl spends her days visiting franchises, managing five members of the leadership team, handling escalated issues and meeting with potential franchisees. All this with a husband, four kids and two dogs of her own. She juggles all this with the help of her smartphone and tablet. Here are three apps she can’t live without:1Password. Ganahl used to be an IT person’s nightmare. She stored all her 400 different passwords for both work and personal into a spreadsheet stored on her computer. And just in case a thief had trouble locating the information, she had helpfully titled the document “Heidi’s Passwords.” She realized the error of her ways last year when her laptop was lost for almost two weeks and panicked trying to change all of her passwords. Without the spreadsheet, she couldn’t remember them and constantly spent valuable time resetting passwords each time she forgot. After the laptop incident, an employee suggested she download 1Password, a solution which logs you into all of the sites and apps you have preprogrammed with just a tap of a single button once logged into the app. She says between not needing to reset passwords or hunt through her spreadsheet the tool saves her at least 30 minutes every day.Related: Travel Tech: 4 Gadgets for Running Your Business on the FlyMy Fitness Pal. Since Ganahl spends at least one week a month on the road for business, eating healthy and exercising regularly is a challenge. Last year nine of her friends who also travel for work formed a support group on the online platform, sharing workouts and diet successes as well as pointers for her sister travelers.  Before she joined her friends on My Fitness Pal she didn’t always fit in her daily workout and found herself eating at the same restaurants that she knew offered healthy food or grabbing less healthy options. But now, she knows that if she skips a workout she has to answer to her friends and they often share ideas for quick meals on the run. “Last week one of the group members posted about a healthy and yummy meal she had in the Chicago airport so next time I pass through on a layover, I am definitely going to eat there,” says GanahlRelated: How to Create a Super Strong Password (Infographic)Orbitz. Earlier this year Ganahl found herself stuck in Los Angeles airport due to flight delays at the same time her husband was leaving on his own out-of-town trip. If she didn’t make it home very soon, no one would be available to care for their 5 year-old and two-year old twins. Ganahl didn’t trek back to the ticket desk, but pulled up the Orbitz app and bought a cheap one-way ticket on another airline that would get her home in time. While she’s used other travel apps, she returns to Orbitz because it saves all of her frequent flier numbers and remembers that she likes to sit by the window so she can look at the landscape. Ganahl estimates that the app saves 20 percent of her time when booking tickets for herself and friends and family.  “Orbitz even remembers that I like to connect through the Minneapolis airport since it’s such a fun spot to hang out.”Related: Wake Up and Kick-Start Your Mornings With These 5 Bright Apps Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. Opinions expressed by Entrepreneur contributors are their own. Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goalslast_img read more


How to Deal With Increasingly Picky BusinessSoftware Buyers

first_img 5 min read When the topic is B2B software, easy-to-use and intuitive aren’t words that usually come to mind. More often, descriptions like clunky or confusing are more appropriate. Here’s another: crappy.Related: Be Sure to Balance SEO and User Experience in Your Web Page DesignWhat is it about software built for businesses, that we expect it to be pretty much unusable? I’m not going to name names, but you know who they are. They’re “powering” the HR, finance, sales and reporting functions of the world’s enterprises and SMBs alike.Dig a bit deeper and you’ll find a few reasons why B2B software has traditionally gotten a pass, despite torturing users with a clunky experience. Notably, the people who green-light the software haven’t been the same ones using the software. And that’s been a problem..In addition, the people actually using the software have seemed tolerant of their crappy user experience (UX) because that’s just part of their job — or so they think. As a software developer myself, I find that sad.Poor UX is also expensive: When you have many, many users, bad UX costs you money, in terms of extra support. In B2B, companies compensate by hiring more humans. But while that gives users the guided tutorials and support they need — creating a negative co-dependency — the companies with the bad UX don’t solve the customers’ problems.But, wait, there’s hope — what I like to call Great UXpectations. Read on.We’ve been guilty of substandard UX ourselves.It’s been almost a decade that HubSpot has been around, and we too have been guilty of delivering a substandard (read: crappy) user experience at times. But we’ve reacted to our customer feedback, and I’m proud to say that our customers now tend to love where HubSpot has gone. It’s been no small investment to get us there.The listening function alone — added to the response — has resulted in significant costs. When you have many, many users (as with B2C), you can amortize the investment in user experience across a broader base. When you have only hundreds of users, it doesn’t matter as much.The hope on the horizon that I alluded to is coming from our collective expectations for a great user experience. That’s true, whether we’re talking about users sharing photos with friends, finding a date or quickly analyzing sales trends from the past quarter. As B2C software has become woven tightly into the fabric of our daily lives, we’ve become far less inclined to differentiate between software that’s for business or pleasure. Because, quite often, those parts of our lives are intertwined.Related: Can ‘User-Experience’ Experts Become ‘Customer-Experience’ Experts?When we look to technology to power our personal lives, the new expectation is that your 85-year-old grandmother should be able to use it. That’s what I mean by “Great UXpectations.” So, what companies are delivering on these Great UXpectations?Shopify, for one, is bringing ecommerce to the masses — bringing stores online in droves. Entrepreneurs are finding Shopify’s user-friendly interface a saving grace for bringing their goods to the global market. Uber is another example of software that provides a seamless solution for getting from point A to point B, regardless of who is paying for it: you or your company.Is Uber easy to use? You bet. Does the company listen to its riders and drivers (actual users) to provide updates to the platform? Yup.Uber also is a good example of the disruptive factor of the next generation of user-friendly (and often free or freemium-model) B2B software. It got its foothold in companies through employees using the app. Those employees then demanded that their own employers get on board and adopt.Others such as Box, Dropbox and Slack (all terrific UX) have penetrated the business through usership among their employee ranks. Notably, that didn’t happen because the afore-mentioned companies knocked down the doors of purchasing or IT departments and CIOs.At HubSpot, we’ve seen great initial results from a few of our most recent products for businesses, including our browser plugin Sidekick, as well as HubSpot CRM. Already, more than 60,000 companies are using our sales platform. We see that as a sign that, like our peers at Dropbox and Slack, users are finding these products really useful.A happy user is a chatty user. He or she tells a colleague — be it a fellow sales team member, a business development associate or, just maybe, the CIO — and the love grows from there.So, if I were to pull out my crystal ball — or maybe just play Captain Obvious for a moment — I’d say that those B2B software companies that aren’t doubling down on UX right now should expect to see their growth stall. There’s just too much opportunity for upstarts to disrupt the technology in businesses one user at a time until adoption becomes inevitable.The consumer is in control now. And the expectations are great.Related: User Experience is Integral to Winning App Design Opinions expressed by Entrepreneur contributors are their own. Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goals August 27, 2015 Register Now »last_img read more


Windows Server 2012 and Windows Embedded 8 Standard get IE11 support

first_imgWindows Server 2012 and Windows Embedded 8 Standard get IE11 support by Martin Brinkmann on January 29, 2019 in Internet Explorer – Last Update: January 29, 2019 – 14 commentsMicrosoft announced today that it plans to make Internet Explorer 11 available to the company’s operating systems Windows Server 2012 and Windows Embedded 8 Standard.Internet Explorer 11 (IE11) is the last version of Internet Explorer that Microsoft released. The company made the decision back when it was released to limit support to some versions of Windows; this meant, essentially, that operating systems such as Windows 8, Windows Server 2012 or Windows Embedded 8 Standard were not support.The release history of Internet Explorer for Windows Server and Windows Embedded operating systems is quite confusing on first glance.Microsoft did not release IE11 for Windows Server 2012 but it did release the browser for Windows Server 2008 R2 Service Pack 1. Similarly, Windows Embedded 8 Standard was limited to Internet Explorer 10 while Windows Embedded Standard 7 received Internet Explorer 11.Microsoft revealed that it will make Internet Explorer 11 available for Windows Server 2012 and Windows Embedded 8 Standard operating systems. The decision had to be made because support for Internet Explorer 10 security updates ends on January 14, 2020.Internet Explorer 11 will be released for the two operating systems; administrators may download IE11 from Microsoft’s Update Catalog website or distribute it using Windows Update or WSUS.The company released the following timeline of events:Spring 2019: Internet Explorer 11 will be offered to commercial customers that run Windows Server 2012 or Windows Embedded Standard 8.Later in 2019: Internet Explorer 11 will become available through Windows Update and Windows Server Update Services.January 2020: end of support for Internet Explorer 10. Microsoft won’t release security updates for the browser anymore.Updates for Internet Explorer 10 and 11 will be labeled as such. Updates for IE10 are labeled Cumulative Update for Internet Explorer 10, and updates for IE11 as Cumulative Update Internet Explorer 11 on all update platforms and the Microsoft Update Catalog.Microsoft won’t offer paid assisted support options to extend the Internet Explorer 10 support period.Support for most Windows Server 2012 versions ends in October 2023, support for Windows Embedded 8 Standard in November 2023.Organizations need to upgrade Internet Explorer 10 on these devices to Internet Explorer 11 to receive security updates for the built-in web browser. Microsoft notes that companies may use Enterprise Mode for application and website compatibility, and that migrating to IE11 will “ease the migration path to Windows 10, Windows Server 2016 or 2019, or Windows 10 IoT”.Now You: Which browser do you use predominantly?SummaryArticle NameWindows Server 2012 and Windows Embedded 8 Standard get IE11 supportDescriptionMicrosoft announced today that it plans to make Internet Explorer 11 available to the company’s operating systems Windows Server 2012 and Windows Embedded 8 Standard.Author Martin BrinkmannPublisher Ghacks Technology NewsLogo Advertisementlast_img read more